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RESEARCH PRODUCT
TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.
Anja NisslerOliver GorkaAri WaismanAri WaismanFlorian MairBurkhard BecherSaskia HemmersSaskia HemmersThorsten BuchThorsten BuchThorsten BuchWerner MüllerAnna SledzinskaJürgen RulandLynsey Fairbairnsubject
Autoimmunity10263 Institute of Experimental ImmunologyT-Lymphocytes RegulatoryMiceInterleukin 210302 clinical medicineTransforming Growth Factor beta2400 General Immunology and MicrobiologyHomeostasisCytotoxic T cellIL-2 receptorBiology (General)0303 health sciencesGeneral Neuroscience2800 General NeurosciencePeripheral toleranceFOXP3ColitisNatural killer T cell3. Good healthCell biologymedicine.anatomical_structureGeneral Agricultural and Biological SciencesResearch ArticleSignal TransductionRegulatory T cellQH301-705.5Receptors Antigen T-Cell610 Medicine & health1100 General Agricultural and Biological SciencesThymus GlandBiologyGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences1300 General Biochemistry Genetics and Molecular BiologyLymphopeniamedicineAnimalsAntigen-presenting cellCell Proliferation030304 developmental biologyInflammationIntegrasesGeneral Immunology and MicrobiologyReproducibility of ResultsMice Inbred C57BLTamoxifenImmunologyNIH 3T3 Cells570 Life sciences; biologyGene Deletion030215 immunologydescription
Signalling by the cytokine TGF-β regulates mature CD4+ T cell populations but is not involved in the survival and function of regulatory T cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-10-01 | PLoS Biology |