6533b870fe1ef96bd12cf2dc
RESEARCH PRODUCT
On the reactivity of nitrosoimidazoles with acids (the Cusmano–Ruccia reaction): a continuous source of new ring-into-ring interconversion
Domenico SpinelliBarbara CosimelliElda SeveriVincenzo FrennaMirella Rambaldisubject
Multi-step processesOrganic ChemistryHydrochloric acidSettore CHIM/06 - Chimica OrganicaRing (chemistry)BiochemistryMedicinal chemistryIonConsedensed nitrosoimidazoles ring-into-ring interconversion multi-step processes 3-acyl-124-oxadiazoleschemistry.chemical_compoundchemistryCondensed nitrosoimidazoleDrug DiscoveryImidazoleAmmoniumReactivity (chemistry)MethanolRing-into-ring interconversionOxazoledescription
Abstract An extension of the ‘Cusmano–Ruccia’ reaction is reported. 6-(4-chlorophenyl)-3-methyl-5-nitrosoimidazo[2,1- b ]oxazole by the action of hydrochloric acid gives 3-(4-chlorobenzoyl)-5-methyl-1,2,4-oxadiazole ( 13 ); presumably via ammonium ion, CO 2 and methanol elimination. The relevance of the nature of the atom of the B -ring linked to C-2 of the imidazole for the occurrence of the ring-into-ring interconversion has been once more confirmed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-02-01 | Tetrahedron Letters |