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RESEARCH PRODUCT

Plasma Hyperosmolality Prolongs QTc Interval and Increases Risk for Atrial Fibrillation in Traumatic Brain Injury Patients

Chiara RobbaWojciech DabrowskiPaulina IwaniukDorota Siwicka-gierobaRafael BadenesMateusz BialyTodd T. SchlegelAndrzej Jaroszyński

subject

Cardiac function curvemedicine.medical_specialtyTraumatic brain injuryosmolar gapelectrocardiographylcsh:Medicine030204 cardiovascular system & hematologyQT intervalArticleCerebral edema03 medical and health sciences0302 clinical medicineInternal medicinemedicine030212 general & internal medicinecardiovascular diseasesbusiness.industrytraumatic brain injurylcsh:RGlasgow Coma ScaleCardiac arrhythmiaAtrial fibrillationGeneral Medicinemedicine.diseaseplasma osmolalityPlasma osmolalitycardiac arrhythmiasCardiologycardiovascular systembusiness

description

Introduction: Hyperosmotic therapy with mannitol is frequently used for treatment cerebral edema, and 320 mOsm/kg H2O has been recommended as a high limit for therapeutic plasma osmolality. However, plasma hyperosmolality may impair cardiac function, increasing the risk of cardiac events. The aim of this study was to analyze the relation between changes in plasma osmolality and electrocardiographic variables and cardiac arrhythmia in patients treated for isolated traumatic brain injury (iTBI). Methods: Adult iTBI patients requiring mannitol infusion following cerebral edema, and with a Glasgow Coma Score below 8, were included. Plasma osmolality was measured with Osmometr 800 CLG. Spatial QRS-T angle (spQRS-T), corrected QT interval (QTc) and STJ segment were calculated from digital resting 12-lead ECGs and analyzed in relation to four levels of plasma osmolality: A) &lt

yearjournalcountryeditionlanguage
2020-04-01Journal of Clinical Medicine
10.3390/jcm9051293http://europepmc.org/articles/PMC7288326