6533b870fe1ef96bd12cf9f1
RESEARCH PRODUCT
Dectin-1 mediatesin vitrophagocytosis ofCandida albicansyeast cells by retinal microglia: Figure 1
Victoria ManeuVictoria ManeuAlberto YáñezM L GilAndrés MolinaCelia MurcianoDaniel Gozalbosubject
Microbiology (medical)MicrogliaPhagocytosisImmunologyRetinalGeneral MedicineBiologybiology.organism_classificationMicrobiologyCorpus albicansMicrobiologychemistry.chemical_compoundTLR2Infectious Diseasesmedicine.anatomical_structurechemistryIntegrin alpha MMacrophage-1 antigenmedicinebiology.proteinImmunology and AllergyCandida albicansdescription
We have investigated the expression of TLR2 and Dectin-1 in retinal microglia and their involvement in Candida albicans phagocytosis using a cytometric approach. The expression of both receptors has been demonstrated in CD11b+ retinal cells. Phagocytosis of pHrodo-labelled C. albicans yeasts by microglial CD11b+ cells of C57BL/6 mice was inhibited both by the Dectin-1 antagonist laminarin and anti-Dectin-1 antibodies, whereas phagocytosis of yeasts by retinal microglia of TLR2 KO mice was unaffected. These data indicate that phagocytosis of C. albicans yeasts by retinal microglia is mediated by Dectin-1, whereas TLR2 does not play a significant role in this process.
year | journal | country | edition | language |
---|---|---|---|---|
2011-10-01 | FEMS Immunology & Medical Microbiology |