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RESEARCH PRODUCT
Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia.
Isabel FariñasMario SorianoMarifé Cano-jaimezElena Bellmuntsubject
Nervous systemCentral nervous systemSensory systemReceptors Nerve Growth FactorBiologyMiceNeurotrophic factorsGanglia SpinalmedicineAnimalsNerve Growth FactorsNeurons AfferentGeneral NeuroscienceStem CellsNeurogenesisNeural crestCell DifferentiationNeural stem cellmedicine.anatomical_structurenervous systemNeural Crestbiology.proteinNeuroscienceNeurogliaCell DivisionNeurotrophindescription
Neurons and glia in spinal sensory ganglia derive from multipotent neural crest-derived stem cells. In contrast to neural progenitor cells in the central nervous system, neural crest progenitors coexist with differentiated sensory neurons all throughout the neurogenic period. Thus, developing sensory ganglia are advantageous for determining the possible influence of cell-cell interactions in the regulation of precursor proliferation and neurogenesis. Neurotrophins are important regulators of neuronal survival in the developing vertebrate nervous system and, in addition, they appear to influence precursor behavior in vitro. Studies in mice carrying mutations in neurotrophin genes provide a good system in which to analyze essential actions of these factors on the different developing neural populations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-05-29 | Brain research bulletin |