6533b870fe1ef96bd12cfd43

RESEARCH PRODUCT

Sumatriptan Succinate Transdermal Delivery Systems for The Treatment of Migraine

S. Del Rio-sanchoC. Balaguer-fernándezA. Femenía-fontAlicia López-castellanoVirginia Merino

subject

PolymersSwineChemistry PharmaceuticalDrug CompoundingMigraine DisordersSkin AbsorptionPharmaceutical Sciencemacromolecular substancesAbsorption (skin)MethylcellulosePharmacologyAdministration CutaneousPermeabilityDosage formchemistry.chemical_compoundPolymethacrylic AcidsPlasticizersSumatriptan SuccinatemedicineAnimalsSorbitolTechnology PharmaceuticalVasoconstrictor AgentsSkinTransdermalDrug Carriersintegumentary systemSumatriptanChemistrytechnology industry and agriculturePlasticizerPovidoneAzepinesIontophoresisPermeationPropylene GlycolSerotonin Receptor AgonistsKineticsSumatriptanPolyvinyl AlcoholMethyl celluloseDiffusion Chambers CultureTissue AdhesivesNuclear chemistrymedicine.drug

description

We have successfully obtained sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propylenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of sumatriptan succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically significant increment with respect to the PVP and PVP-PVA formulations (p0.05). Azone incorporation into the systems produced an increment in the sumatriptan flux values of all three transdermal systems with respect to those of the controls (p0.05). In addition, the application of iontophoresis to the wet methyl cellulose-Azone formulation produced a much higher increase of sumatriptan transdermal flux.

yearjournalcountryeditionlanguage
2007-09-15Journal of Pharmaceutical Sciences
https://doi.org/10.1002/jps.21129