6533b870fe1ef96bd12cfd4d

RESEARCH PRODUCT

Amphiphilic Polysaccharide Block Copolymers for pH-Responsive Micellar Nanoparticles

Ira SchmidPeter WichBenjamin B. Breitenbach

subject

AzidesPolymers and PlasticsNanoparticleBioengineering02 engineering and technology010402 general chemistry01 natural sciencesReductive aminationBiomaterialsSurface-Active Agentschemistry.chemical_compoundAmphiphileMaterials ChemistryCopolymerOrganic chemistryMicrowavesMicellesAqueous solutionChemistryDextransHydrogen-Ion Concentration021001 nanoscience & nanotechnology0104 chemical sciencesDextranChemical engineeringAlkynesCritical micelle concentrationClick chemistryNanoparticlesClick Chemistry0210 nano-technologyHydrophobic and Hydrophilic InteractionsCopper

description

A full polysaccharide amphiphilic block copolymer was prepared from end group-functionalized dextrans using copper-mediated azide-alkyne click chemistry. Sufficient modification of the reducing end in both blocks was achieved by microwave-enhanced reductive amination in a borate-buffer/methanol solvent system. The combination of a hydrophilic dextran block with a hydrophobic acetalated dextran block results in an amphiphilic structure that turns water-soluble upon acid treatment. The material has a low critical micelle concentration and self-assembles in water to spherical micellar nanoparticles. The formed nanoparticles have a narrow size distribution below 70 nm in diameter and disassemble in slightly acidic conditions. The amphiphilic polysaccharide system shows low toxicity and can stabilize the hydrophobic model drug curcumin in aqueous solutions over extended time periods.

yearjournalcountryeditionlanguage
2017-08-15Biomacromolecules
https://doi.org/10.1021/acs.biomac.7b00771