6533b870fe1ef96bd12cfd7a
RESEARCH PRODUCT
Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C-H monoarylation.
Oumaima AbidiJulien RogerTaoufik BoubakerJean-cyrille Hiersosubject
chemistry.chemical_classificationSolvent free010405 organic chemistryChemistryOrganic Chemistrychemistry.chemical_element010402 general chemistry01 natural sciencesBiochemistryCombinatorial chemistry0104 chemical sciencesRutheniumchemistry.chemical_compoundSulfonateReagentSurface modificationAzolePhysical and Theoretical ChemistrySelectivityTrifluoromethanesulfonatedescription
Metal-catalysed ortho-directed C–H functionalization usually faces selectivity issues in the competition between mono- and disubstitution processes. We report herein the ruthenium-catalysed N-directed C–H monoarylation of arylpyrazoles with a selectivity of up to 96% or that generally reaches values above 80%. This selectivity is an effect of solvent-free conditions associated with sulfonate reagents, in the absence of frequently used acidic additives.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-06-01 | Organicbiomolecular chemistry |