Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives

6533b870fe1ef96bd12cfd93

RESEARCH PRODUCT

Extracellular Vesicles and Tumor-Immune Escape: Biological Functions and Clinical Perspectives

Stefania Raimondo Marzia Pucci Riccardo Alessandro Riccardo Alessandro Simona Fontana

subject

animal diseases Cell Programmed Cell Death 1 Receptor chemical and pharmacologic phenomena pd-1/pd-l1 axis Review Biology Catalysis Immune tolerance Inorganic Chemistry lcsh:Chemistry Extracellular Vesicles Immune system Neoplasms medicine Immune Tolerance Animals Humans Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Mechanism (biology)Organic Chemistry Cancer General Medicine biochemical phenomena metabolism and nutrition immune checkpoints medicine.disease Phenotype Computer Science Applications Cell biology extracellular vesicles (evs) cancer immune tolerance The Hallmarks of Cancer medicine.anatomical_structure lcsh:Biology (General)lcsh:QD1-999 Cancer cell bacteria Tumor Escape Immune checkpoint Immunotherapy extracellular vesicles (EVs)cancer immune tolerance

description

The modulation of the immune system is one of the hallmarks of cancer. It is now widely described that cancer cells are able to evade the immune response and thus establish immune tolerance. The exploration of the mechanisms underlying this ability of cancer cells has always attracted the scientific community and is the basis for the development of new promising cancer therapies. Recent evidence has highlighted how extracellular vesicles (EVs) represent a mechanism by which cancer cells promote immune escape by inducing phenotypic changes on different immune cell populations. In this review, we will discuss the recent findings on the role of tumor-derived extracellular vesicles (TEVs) in regulating immune checkpoints, focusing on the PD-L1/PD-1 axis.

year	journal	country	edition	language
2020-03-01	International Journal of Molecular Sciences

10.3390/ijms21072286 https://www.mdpi.com/1422-0067/21/7/2286

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