Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat

6533b870fe1ef96bd12cfdb2

RESEARCH PRODUCT

Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat

Juan V. Esplugues Elena Rubio J Esplugues Francisco J. Morales-olivas Julio Cortijo

subject

Male medicine.medical_specialty Contraction (grammar)Carbachol Pharmaceutical Science In Vitro Techniques Inhibitory postsynaptic potential Potassium Chloride Diltiazem Internal medicine Animals Potency Medicine Diltiazem Pharmacology business.industry Muscle Smooth Benzazepines Rats Endocrinology Verapamil cardiovascular system Verapamil Carbachol Female Esophagogastric Junction medicine.symptom business Acetylcholine Muscle Contraction Muscle contraction medicine.drug

description

Abstract The effect of verapamil and diltiazem on the contraction induced by agonists on the rat lower oesophageal sphincter in-vitro has been studied. Both calcium entry blockers inhibited the contractile response to acetylcholine, carbachol and KCl. The potency of the inhibitory action was diltiazem &gt; verapamil. The results give substance to the use of calcium entry blockers in the treatment of oesophageal spasm.

year	journal	country	edition	language
1985-03-01	Journal of Pharmacy and Pharmacology

https://doi.org/10.1111/j.2042-7158.1985.tb05044.x

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