6533b870fe1ef96bd12cfdeb
RESEARCH PRODUCT
Stereoselective Synthesis of 3-Substituted and 3,4-Disubstituted Piperidine und Piperidin-2-one Derivatives
Horst KunzEllen Klegrafsubject
chemistry.chemical_compoundNucleophilic additionchemistryReagentAmideElectrophileStereoselectivityGeneral ChemistryPiperidineMedicinal chemistrydescription
The stereoselective synthesis of 3-substituted and 3,4-disubstituted piperidine and piperidin-2-one derivatives was achieved starting from 2-pyridone. After N-galactosylation and subsequent O-silylation, nucleophilic addition of organometallic reagents proceeded with high regio- and stereoselectivity at 4-position. Substituents at position 3 were stereoselectively introduced by reaction of electrophiles with amide enolates of the N-galactosyl-2-piperidones.
year | journal | country | edition | language |
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2012-04-01 | Zeitschrift für Naturforschung B |