6533b870fe1ef96bd12cfdf9
RESEARCH PRODUCT
Cathepsin L in metastatic bone disease: therapeutic implications
Marilena CrescimannoMaria Vittoria SepportaFrancesca Maria TumminelloCarla FlandinaGaetano Letosubject
Bone diseaseClinical BiochemistryBone NeoplasmsBone metastasis; cancer; cathepsin K; cathepsin L; cysteine proteinases; proteinase inhibitorsBiologycathepsin KBiochemistryBone and BonesBone resorptioncathepsin LBone remodelingcysteine proteinaseCathepsin LmedicineCathepsin KAnimalsHumanscancerNeoplasm MetastasisMolecular BiologyCathepsinProteolytic enzymesproteinase inhibitorsBone metastasismedicine.diseaseBone metastasiCancer researchbiology.proteinSettore BIO/14 - Farmacologiadescription
AbstractCathepsin L is a lysosomal cysteine proteinase primarily devoted to the metabolic turnover of intracellular proteins. However, accumulating evidence suggests that this endopeptidase might also be implicated in the regulation of other important biological functions, including bone resorption in normal and pathological conditions. These findings support the concept that cathepsin L, in concert with other proteolytic enzymes involved in bone remodeling processes, could contribute to facilitate bone metastasis formation. In support of this hypothesis, recent studies indicate that cathepsin L can foster this process by triggering multiple mechanisms which, in part, differ from those of the major cysteine proteinase of osteoclasts, namely cathepsin K. Therefore, cathepsin L can be regarded as an additional target in the treatment of patients with metastatic bone disease. This review discusses the clinical and therapeutic implications related to these findings.
year | journal | country | edition | language |
---|---|---|---|---|
2010-06-01 |