6533b870fe1ef96bd12cfe09
RESEARCH PRODUCT
Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast.
Francisco Estruchsubject
GeneticsbiologySaccharomyces cerevisiaeGenes FungalTrehaloseSaccharomyces cerevisiaebiology.organism_classificationMicrobiologyPhenotypeYeastCell biologyOxidative StressInfectious DiseasesOsmotic PressureHeat shock proteinHeat shockSignal transductionGeneTranscription factorHeat-Shock ProteinsHeat-Shock ResponseSignal TransductionTranscription Factorsdescription
The transcriptional response to environmental changes is a major topic in both basic and applied research. From a basic point of view, to understand this response includes unravelling how the stress signal is sensed and transduced to the nucleus, to identify which genes are induced under each stress condition and, finally, to establish the phenotypic consequences of this induction in stress tolerance. The possibility of using genetic approaches has made the yeast Saccharomyces cerevisiae a compelling model to study stress response at a molecular level. Moreover, this information can be used to isolate and characterise stress-related proteins in higher eukaryotes and to design strategies to increase stress resistance in organisms of industrial interest. In this review the progress made in recent years is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-10-01 | FEMS microbiology reviews |