6533b870fe1ef96bd12cfe0c

RESEARCH PRODUCT

Plasma levels of lipoproteins and apolipoproteins in congenital hypothyroidism: Effects of l-thyroxine substitution therapy

Angelo B. CefalùAngelo B. CefalùAndrea LiottaAndrea LiottaCristina MaggioCristina MaggioStefania La GruttaStefania La GruttaCarlo M. BarbagalloCarlo M. BarbagalloAlberto NotarbartoloAlberto NotarbartoloMaurizio AvernaMaurizio AvernaLucia CasimiroLucia Casimiro

subject

Maleendocrine systemmedicine.medical_specialtyApolipoprotein BLipoproteinsEndocrinology Diabetes and MetabolismThyrotropinTriglyceridechemistry.chemical_compoundEndocrinologyHypothyroidismInternal medicineBlood plasmaCongenital HypothyroidismHumansMedicineLipoproteinTriglyceridesTriiodothyronineApolipoprotein A-Ibiologybusiness.industryCholesterolThyroidInfant NewbornInfantmedicine.diseaseApolipoproteinApolipoproteins; Humans; Infant Newborn; Lipoproteins HDL; Apolipoprotein A-I; Cholesterol; Thyrotropin; Infant; Congenital Hypothyroidism; Triglycerides; Lipoproteins; Thyroxine; Hypothyroidism; Lipoproteins LDL; Female; MaleCongenital hypothyroidismLipoproteins LDLThyroxineApolipoproteinsCholesterolEndocrinologymedicine.anatomical_structurechemistrybiology.proteinFemalelipids (amino acids peptides and proteins)Lipoproteins HDLbusinessHumanLipoproteinHormone

description

Thyroid status in humans is an important factor in the regulation of lipoprotein metabolism. There are several data on hypothyroidism in the adult population, but less information is available about congenital hypothyroidism. Since lipid metabolism at birth is substantially different from that of adults, it is not likely that the same abnormalities that occur in adult hypothyroidism are also present when this is diagnosed at early life. We studied 16 subjects with congenital hypothyroidism, seven at the time of diagnosis and also after normalization of thyroid hormone levels over a period of 2.0 +/- 1.0 months of substitution therapy with L-thyroxine (5.9 +/- 1.2 micrograms/kg/d) and nine already on L-thyroxine therapy for a period of 4.7 +/- 3.2 months. Thirty-nine apparently healthy subjects matched for age were selected as controls. In all subjects, total cholesterol (CHO), triglycerides (TG), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol (HDL-C), apolipoproteins (apo) A-I and B, lipoprotein(a) [Lp(a)] thyrotropin (TSH), (LDL-C), total and free thyroxine (T4), and triiodothyronine (T3) were determined. CHO, HDL-C, and apo A-I levels were significantly higher in patients at the time of diagnosis than in controls (respectively, P = .0079, .0007, and .0004), whereas TG, LDL-C, apo B, and Lp(a) levels were not significantly different. During L-thyroxine substitution therapy in these subjects, HDL-C and apo A-I levels significantly decreased (respectively, by a mean of -36.2% and -24.4%), with similar behavior in all subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

yearjournalcountryeditionlanguage
1995-10-01Metabolism
https://doi.org/10.1016/0026-0495(95)90030-6