6533b870fe1ef96bd12d01d3
RESEARCH PRODUCT
Inverse relationship between body mass index and mortality in older nursing home residents: A meta-analysis of 19,538 elderly subjects
N VeroneseE CeredaM SolmiS. A FowlerE ManzatoS MaggiP ManuE AbeK HayashiJ. P AllardB. M ArendtA BeckM ChanY. J. P AudreyW. Y LinH. S HsuC. C LinR DiekmannS KimyagarovM MillerI. D CameronK. H PitkäläJ LeeJ WooK NakamuraD SmileyG UmpierrezM RondanelliM Sund LevanderL ValentiniK SchindlerJ TörmäStefano VolpatoGiovanni ZulianiM WongK LokJ. M KaneG SergiC. U. Correllsubject
MaleFrail ElderlySocio-culturaleelderlyBody mass index;elderly;mortality;nursing homenursing home.EndocrinologyThinnessRisk FactorsHomes for the AgedHumansNutritional Physiological PhenomenaBody mass indexAgedAged 80 and overBody mass index; Elderly; Mortality; Nursing home; Public Health Environmental and Occupational Health; Endocrinology Diabetes and MetabolismNursing homeEnvironmental and Occupational HealthPublic Health Global Health Social Medicine and EpidemiologyBody mass index elderly mortality nursing homeOverweightmortalityNursing HomesDiabetes and MetabolismFolkhälsovetenskap global hälsa socialmedicin och epidemiologiFemalePublic Healthdescription
Body mass index (BMI) and mortality in old adults from the general population have been related in a U-shaped or J-shaped curve. However, limited information is available for elderly nursing home populations, particularly about specific cause of death. A systematic PubMed/EMBASE/CINAHL/SCOPUS search until 31 May 2014 without language restrictions was conducted. As no published study reported mortality in standard BMI groups (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2), the most adjusted hazard ratios (HRs) according to a pre-defined list of covariates were obtained from authors and pooled by random-effect model across each BMI category. Out of 342 hits, 20 studies including 19,538 older nursing home residents with 5,223 deaths during a median of 2 years of follow-up were meta-analysed. Compared with normal weight, all-cause mortality HRs were 1.41 (95% CI = 1.26–1.58) for underweight, 0.85 (95% CI = 0.73–0.99) for overweight and 0.74 (95% CI = 0.57–0.96) for obesity. Underweight was a risk factor for higher mortality caused by infections (HR = 1.65 [95% CI = 1.13–2.40]). RR results corroborated primary HR results, with additionally lower infection-related mortality in overweight and obese than in normal-weight individuals. Like in the general population, underweight is a risk factor for mortality in old nursing home residents. However, uniquely, not only overweight but also obesity is protective, which has relevant nutritional goal implications in this population/setting. Funding agencies: Baxter; Abbott; Fresenius-Kabi; Pfizeer; Nestle; Sanofi; Novo Nordisk; Boehringer Ingelheim; Merck; BMS; Feinstein Institute for Medical Research; Janssen/JJ; National Institute of Mental Health (NIMH); National Alliance for Research in Schizophrenia and
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-04-09 |