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RESEARCH PRODUCT

Additional file 2 of COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection

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Additional file 2: Figure S1. Pairwise distances along 259 full length CoV genomes. In the bottom of picture, indicative gene positioning along CoVs genomes is reported. The list of all considered genomes is reported in Additional file 1: Table S1. Figure S2. 3D structure of S-glycoprotein of SARS-CoV-2 and comparison with the ortholog from HCoV-229E, SARS-CoV, and MERS-CoV. Lateral (a) and superior (b) representation of SARS-CoV-2 S-glycoprotein, deducted for the sequence of patient INMI1 (MT066156.1). Each subunit chain has a different color. Structure comparison of S-glycoprotein subunit between: HCoV-229E and SARS-CoV-2, in purple and blue respectively (c); SARS-CoV and SARS-CoV-2, in red and blue, respectively (d); MERS-CoV and SARS-CoV-2, in green and blue, respectively (e). Figure S3. Amino acid alignment and secondary motifs in the receptor binding domain (RBD) of S-glycoprotein of HCoV-229E, SARS-CoV, MERS-CoV and SARS-CoV-2 are shown. Legend of secondary motifs identifiers: H = α Helix, E = β Sheet, X = Random coil. Figure S4. HCoV-229E–host interactome resulting from RWR applied to the top 200 closest proteins identified by RWR, using S-glycoprotein of HCoV-229E. Figure S5. SARS-CoV–host interactome resulting from RWR applied to the top 200 closest proteins identified by RWR, using S-glycoprotein of SARS-CoV. Figure S6. MERS-CoV–host interactome resulting from RWR applied to the top 200 closest proteins identified by RWR, using S-glycoprotein of MERS-CoV.