6533b870fe1ef96bd12d064c
RESEARCH PRODUCT
Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease.
Hannsjo¨rg Schro¨derKarl ZillesRobert G. StrubleAlfred MaelickeEzio Giacobinisubject
Malemedicine.medical_specialtyAgingImmunocytochemistryBiologyReceptors NicotinicImmunoenzyme TechniquesPostsynaptic potentialAlzheimer DiseaseInternal medicineOxazinesmedicineHumansReceptorAcetylcholine receptorAgedNeuronsImmunoperoxidaseGeneral NeuroscienceAntibodies Monoclonalmedicine.diseaseBenzoxazinesFrontal Lobemedicine.anatomical_structureEndocrinologyNicotinic agonistCerebral cortexFemaleNeurology (clinical)Geriatrics and GerontologyAlzheimer's diseaseDevelopmental Biologydescription
The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex (area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged controls using the monoclonal antibody WF 6 and an immunoperoxidase protocol. Statistical analysis revealed significant differences between the number of labeled neurons among all three groups tested (middle-aged controls greater than aged controls greater than Alzheimer cases). No differences were seen for cresyl violet-stained samples. These findings underline that the nicotinic receptor decrease found with radioligand binding may reflect a postsynaptic in addition to a presynaptic component.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-05-01 | Neurobiology of aging |