6533b870fe1ef96bd12d0792
RESEARCH PRODUCT
Facile synthesis of 2-nitroalkanols by tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones
Marinella RobertiIlaria LamprontiDaniele SimoniGian Piero PolliniR. FerroniFrancesco Paolo InvidiataStefano Manfredinisubject
chemistry.chemical_classificationAlicyclic compoundPrimary (chemistry)Nitroaldol reactionChemistryOrganic ChemistryDrug DiscoveryOrganic chemistryBiochemistryCatalysisdescription
Abstract Tetramethylguanidine-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones constitutes a practical means to perform the nitro-aldol reaction (Henry reaction). The very mild conditions employed, together with the short reaction times, make the procedure tolerant of a range of functionalities and highly versatile for the synthesis of a variety of 2-nitroalkanols.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-04-01 | Tetrahedron Letters |