6533b870fe1ef96bd12d0809
RESEARCH PRODUCT
High pressure liquid chromatography resolution of racemic mixtures of chiral tricarbonyl arene chromium(0) and cyclopentadienyl-titanium(IV) complexes
Carlo RosiniGiovanni VitulliFederica BorgheriniJack BesançonClaude MoïsePaolo PerticiPiero Salvadorisubject
Resolution (mass spectrometry)ChemistryAbsolute configurationchemistry.chemical_elementMedicinal chemistryHigh-performance liquid chromatographyInorganic ChemistryHexanechemistry.chemical_compoundChromiumCyclopentadienyl complexMaterials ChemistryOrganic chemistryPhysical and Theoretical ChemistryEnantiomerSelectivitydescription
Abstract Enantiomers of chiral tricarbonyl arene chromium(0) and cyclopentadienyl-titanium(IV) complexes have been separated by high pressure liquid chromatography employing a Chiralcel OD (Daicel) column, eluting with hexane/2-propanol mixtures. The capacity factors ( k ) and selectivity factors ( α ) concerning the separation of these compounds have been determined. The resolution of tricarbonyl( η 6 -methyl o -acetylbenzoate)chromium ( IV ), was carried out on semipreparative scale: a comparison of the CD spectra of the enantiomers IVa and IVb with that reported in the literature for a similar complex allowed to establish the absolute configuration [( 1R )] for the most retained enantiomer IVa .
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-02-01 | Inorganica Chimica Acta |