High pressure liquid chromatography resolution of racemic mixtures of chiral tricarbonyl arene chromium(0) and cyclopentadienyl-titanium(IV) complexes

Abstract Enantiomers of chiral tricarbonyl arene chromium(0) and cyclopentadienyl-titanium(IV) complexes have been separated by high pressure liquid chromatography employing a Chiralcel OD (Daicel) column, eluting with hexane/2-propanol mixtures. The capacity factors ( k ) and selectivity factors ( α ) concerning the separation of these compounds have been determined. The resolution of tricarbonyl( η 6 -methyl o -acetylbenzoate)chromium ( IV ), was carried out on semipreparative scale: a comparison of the CD spectra of the enantiomers IVa and IVb with that reported in the literature for a similar complex allowed to establish the absolute configuration [( 1R )] for the most retained enantiom…