6533b871fe1ef96bd12d0e98
RESEARCH PRODUCT
An LD50model for predicting psychotropic drug toxicity using biopartitioning micellar chromatography
M.j. Medina-hernándezC. Quiñones‐torreloRosa María Villanueva-camañasS. Sagrado‐vivessubject
PharmacologyDrugAlternative methodsChromatographyChemistrymedia_common.quotation_subjectClinical BiochemistryGeneral MedicinePharmacologyBiochemistryAcute toxicityAnalytical ChemistryPsychotropic drugMicellar liquid chromatographyDrug DiscoveryToxicityMolecular Biologymedia_commonPotential toxicitydescription
The LD50 determination is the main way to measure the acute toxicity of all types of substances. At the present time, however, there is increasing opposition to the use of living animals in research and testing activities from animal rights groups as well as some scientists. Nevertheless, the need to have a tool for estimating the potential toxicity of new compounds for human consumption has encouraged the development of alternative methods. Under adequate conditions, the partitioning in micellar liquid chromatography can describe the drug biopartitioning. We have named this chromatographic system biopartitioning micellar chromatography (BMC). In this paper, an LD50 QRAR model developed for psychotropic drugs from their retention data in BMC, is described. The model's ability to predict new psychotropic drug toxicity is statistically proved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-02-01 | Biomedical Chromatography |