6533b871fe1ef96bd12d0ebe
RESEARCH PRODUCT
An Unprecedented Iridium(III) Catalyst for Stereoselective Dimerisation of Terminal Alkynes
Marco CiclosiFrancisco EstevanJulia Pérez-prietoVincenzo PassarelliVincenzo PassarelliMercedes SanaúPascual Lahuertasubject
TrisHydridechemistry.chemical_elementGeneral ChemistryChlorideMedicinal chemistryCatalysischemistry.chemical_compoundchemistryPhenylacetylenePyridinemedicineOrganic chemistryStereoselectivityIridiummedicine.drugdescription
A novel iridium(III) hydride complex, IrHCl(TIMP 3 ) {HTIMP 3 = tris[1-(diphenylphosphino)-3-methyl-lH-indol-2-yl]methane) was prepared and fully characterized in both the solid state and in solution. Chloride abstraction by silver cations provides a more reactive compound, [IrH-(TIMP 3 )][BF 4 ], which can react with pyridine (py) and phenylacetylene to yield the complexes [IrH-(TIMP 3 )(py)][BF 4 ] and [Ir(PhCH=C-CH=CHPh)-(TIMP 3 )][BF 4 ], respectively. Interestingly, IrH-(TIMP 3 )(py)][BF 4 ] efficiently catalyses the stereoselective dimerisation of model terminal alkynes to the 1,4-disubstituted (E)-but-1-en-3-yne only.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-25 | Advanced Synthesis & Catalysis |