6533b871fe1ef96bd12d0f34
RESEARCH PRODUCT
Increased helper cell activity of NZB mice against H-2-identical allogeneic cells.
U. BotzenhardtJ. Müller-quernheimIvan LefkovitsD. V. Steldernsubject
MaleCellular immunityImmunologyAntigen-Presenting Cellschemical and pharmacologic phenomenaStimulationMice Inbred StrainsBiologyAutoimmune DiseasesMiceAntigenmedicineImmunology and AllergyCytotoxic T cellAnimalsAutoantibodiesAutoimmune diseaseMice Inbred BALB CMice Inbred NZBH-2 AntigensGeneral MedicineT lymphocyteT-Lymphocytes Helper-Inducermedicine.diseaseHistocompatibilityDisease Models AnimalHumoral immunityImmunologyFemaledescription
The T cells of NZB mice become hyperreactive after stimulation with minor histocompatibility (MIH) antigens. This hyperreactivity has previously been demonstrated only for cytotoxic T cells of NZB, although there was some evidence for an increase of their T-helper cell activity facilitating the response. Here we report a quantitative analysis of T-cell help and help of T-cell subpopulations against autologous, MIH, and H-2 antigens in a limiting dilution assay. After stimulation of NZB T cells with autologous and H-2 antigens, the T-helper cell frequencies did not differ from that of normal mice. After stimulation with MIH antigens however, Lyt 1<sup>+</sup>2<sup>+</sup> T-cells of NZB showed a higher response than those of BALB/c origin. The same difference was seen after prestimulation with ConA or the specific antigen. This demonstrates that NZB-helper cells are more easily activated by weak antigenic differences, and it is possible that this contributes to the prevalence of autoimmune disease in this strain.
year | journal | country | edition | language |
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1988-01-01 | International archives of allergy and applied immunology |