6533b871fe1ef96bd12d0fb3

RESEARCH PRODUCT

Magnetic resonance imaging of (1)H long lived states derived from parahydrogen induced polarization in a clinical system.

Hans Wolfgang SpiessLaura M. SchreiberMaria Belen FranzoniKerstin MünnemannDirk Graafen

subject

Nuclear and High Energy PhysicsMagnetic Resonance SpectroscopyVinyl CompoundsSpin statesProtonRadio WavesCiencias FísicasBiophysics010402 general chemistrySpin isomers of hydrogen01 natural sciencesBiochemistryMagnetizationNuclear magnetic resonanceElectromagnetic FieldsPARAHYDROGENHyperpolarization (physics)Singlet stateHYPERPOLARIZATIONPHIP010405 organic chemistryChemistryPULSE SEQUENCEPulse sequenceNuclear magnetic resonance spectroscopyCondensed Matter PhysicsMagnetic Resonance Imaging0104 chemical sciencesAstronomíaLONG LIVED STATECondensed Matter::Strongly Correlated ElectronsProtonsCIENCIAS NATURALES Y EXACTASHydrogen

description

Hyperpolarization is a powerful tool to overcome the low sensitivity of nuclear magnetic resonance (NMR). However, applications are limited due to the short lifetime of this non equilibrium spin state caused by relaxation processes. This issue can be addressed by storing hyperpolarization in slowly decaying singlet spin states which was so far mostly demonstrated for non-proton spin pairs, e.g. 13C-13C. Protons hyperpolarized by parahydrogen induced polarization (PHIP) in symmetrical molecules, are very well suited for this strategy because they naturally exhibit a long-lived singlet state. The conversion of the NMR silent singlet spin state to observable magnetization can be achieved by making use of singlet-triplet level anticrossings. In this study, a low-power radiofrequency pulse sequence is used for this purpose, which allows multiple successive singlet-triplet conversions. The generated magnetization is used to record proton images in a clinical magnetic resonance imaging (MRI) system, after 3 min waiting time. Our results may open unprecedented opportunities to use the standard MRI nucleus 1H for e.g. metabolic imaging in the future. Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; Alemania Fil: Franzoni, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Max Planck Institute for Polymer Research; Alemania Fil: Schreiber, Laura M.. Johannes Gutenberg University Medical Center; Alemania Fil: Spiess, Hans W.. Max Planck Institute for Polymer Research; Alemania Fil: Münnemann, Kerstin. Max Planck Institute for Polymer Research; Alemania

yearjournalcountryeditionlanguage
2015-10-25Journal of magnetic resonance (San Diego, Calif. : 1997)
10.1016/j.jmr.2015.12.006https://pubmed.ncbi.nlm.nih.gov/26754064