6533b871fe1ef96bd12d0fd7
RESEARCH PRODUCT
Retrovirus infection and aging: Increase in UAG suppressor tRNA expression in aged mice.
H. MizushimaW. E. G. MüllerHeinz-christoph SchröderDurdica UgarkovicFumiko NemotoY. Kuchinosubject
chemistry.chemical_classificationAgingHealth (social science)biologybiology.organism_classificationMolecular biologyStop codonlaw.inventionGlutamineRetrovirusEnzymechemistryBiochemistrylawGene expressionTransfer RNASuppressorGeriatrics and GerontologyGerontologyGenedescription
Summary The effect of aging on expression of a natural glutamine suppressor tRNA (tRNA Gln(UmUG) ) was studied in different tissues of mice; this tRNA recognizes UAG and inserts glutamine at the site of the termination codon. The level of tRNA Gln(UmUG) was found to be strongly increased in aged mice, compared to newborn and mature animals. An elevated expression of tRNA Gln(UmUG) has also been found in retrovirus-infected cells; in Moloney virus-infected cells the suppressor tRNA allows to read-through the UAG codon within the retroviral protease gene. We suggest that the increase in the level of tRNA Gln(UmUG) may influence retroviral gene expression with age.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-01-01 | Archives of gerontology and geriatrics |