6533b871fe1ef96bd12d1088
RESEARCH PRODUCT
Paracrine dialogue in implantation
Carlos SimónFrancisco DomínguezFrancisco DomínguezAntonio Pellicersubject
Leptinmedicine.medical_specialtyReceptors Cell SurfaceBiologyEndometriumBiochemistryEndometriumParacrine signallingEndocrinologyPregnancyInternal medicineParacrine CommunicationCell AdhesionmedicineHumansEmbryo ImplantationEndotheliumBlastocystGonadal Steroid HormonesMolecular Biologyurogenital systemMechanism (biology)Mucin-1Epithelial CellsEmbryoEmbryo TransferEmbryonic stem cellCell biologyAppositionBlastocystmedicine.anatomical_structureEndocrinologyCytokinesReceptors LeptinFemaleChemokinesCarrier ProteinsCorpus luteumdescription
We know that the implantation process requires a functionally normal embryo at the blastocyst stage and a receptive endometrium, but also a communication link between them is needed. This paracrine dialogue between the embryo, endometrium and the corpus luteum are known to occur in ruminants and primates, more specifically endometrial-embryonic interactions have been reported in rodents and primates but not in humans. This process is a highly regulated mechanism and many molecules take part in this cross-talk. Here, we present updated information in humans on the embryonic regulation of endometrial epithelial molecules such as chemokines, adhesion and anti-adhesion molecules, and leptin during the apposition and adhesion phases of human implantation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-03-20 | Molecular and Cellular Endocrinology |