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RESEARCH PRODUCT

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Lenka ForetovaSophia S. WangHans-olov AdamiHans-olov AdamiDemetrius AlbanesAndrew D. ZelenetzEmanuele AngelucciPaige M. BracciHervé TillyHervé GhesquièresJohn J. SpinelliKimberly A. BertrandFrancine LadenRebecca D. JacksonWendy CozenAnne J. NovakCharles C. ChungMeredith YeagerBrian C.-h. ChiuJenny TurnerMelissa C. SoutheyGianluca SeveriGianluca SeveriSimonetta Di LolloLindsay M. MortonMark LiebowTheodore R. HolfordPaolo BoffettaPaul I.w. De BakkerJoseph VijaiClaire M. VajdicAnne KrickerMark P. PurdueStephanie J. WeinsteinAhmet DoganAlain MonnereauPatricia HartgeDegui ZhiAmy K. HutchinsonBrenda M. BirmannCharles LawrenceElizabeth A. HollyMarco RaisAnneclaire J. De RoosAnneclaire J. De RoosKarin E. SmedbySonja I. BerndtStephen J. ChanockLucia CondeStephen M. AnsellYan W. AsmannYuanqing YeDavid G. CoxElio RiboliJoseph F. FraumeniChristine F. SkibolaChristopher R. FlowersAngela Brooks-wilsonAngela Brooks-wilsonAmelie S. VeronJarmo VirtamoDanylo J. VillanoThierry Jo MolinaW. Ryan DiverJames D. MckayKenneth OffitEve RomanJinyan HuangXifeng WuMarc MaynadieYolanda BenaventeBaoshan MaBaoshan MaBrian K. LinkThomas E. WitzigMads MelbyeMads MelbyeGeorge J. WeinerZhaoming WangCorinne HaiounAlex SmithAnthony StainesAnne Zeleniuch-jacquotteMartyn T. SmithPaul BrennanNilanjan ChatterjeeTracy LightfootEleanor KaneBengt GlimeliusBengt GlimeliusJu-hyun ParkRobert J. KleinAlexandra NietersHeiner BoeingMariagrazia ZuccaNathaniel RothmanJacqueline ClavelQing LanSusan L. SlagerRudolph KaaksDiana ZelenikaNikolaus BeckerHenrik HjalgrimRachel S. KellyRachel S. KellyRoel VermeulenGraham G. GilesGraham G. GilesAnne TjønnelandCarrie A. ThompsonLaurie BurdettRichard K. SeversonDimitrios TrichopoulosDimitrios TrichopoulosYawei ZhangKari E. NorthTongzhang ZhengJian GuEdward GiovannucciJacques RibySimon CrouchGilles SallesGilles SallesSilvia De SanjoséDennis D. WeisenburgerThomas M. HabermannPaolo VineisLesley F. TinkerJoshua N. SampsonLiming LiangPeter KraftJames R. CerhanLauren R. Teras

subject

LimfomesGenotypeChronic lymphocytic leukemiaCèl·lules BQuantitative Trait LociPopulationFollicular lymphomaGenome-wide association studySingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideArticleWhite PeopleGeneticsGenetic predispositionmedicineHumansGenetic Predisposition to DiseaseeducationGenetic associationGeneticsLikelihood Functionseducation.field_of_studyB cellsChromosome MappingComputational Biologymedicine.diseaseGenetic Locilarge B cell lymphoma (DLBCL)LymphomasLymphoma Large B-Cell DiffuseDiffuse large B-cell lymphomaGenome-Wide Association Study

description

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL. © 2014 Nature America, Inc. All rights reserved.

yearjournalcountryeditionlanguage
2014-01-01
10.1038/ng.3105https://dspace.library.uu.nl/handle/1874/305083