6533b871fe1ef96bd12d10e7

RESEARCH PRODUCT

NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging

Carsten KrollPatrick J. RissFrank RöschVerena Nagel

subject

PhenylacetatesStereochemistryChemistry PharmaceuticalClinical BiochemistryLysinePharmaceutical ScienceGallium RadioisotopesIn Vitro TechniquesBiochemistryChemical synthesisHeterocyclic Compounds 1-Ringchemistry.chemical_compoundHeterocyclic CompoundsDrug DiscoveryChelationBifunctionalMolecular BiologyChelating AgentsPhenylacetatesRadioisotopesOrganic ChemistryHydrogen-Ion ConcentrationModels ChemicalchemistryAminosugarDrug DesignIsotope LabelingPositron-Emission TomographyMolecular MedicineChemical stabilityMolecular imaging

description

This report concerns synthesis, (68)Ga-radiolabelling and stability data of 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothio-cyanatophenyl-acetic acid (NODAPA-NCS), 1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenyl-acetic acid (NODAPA-(NCS)(2)) and 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenyl-acetic acid (NODAPA-OH), versatile bifunctional chelators with potential for molecular imaging. Protein binding and exemplified conjugation are also reported.

yearjournalcountryeditionlanguage
2008-07-31Bioorganic & Medicinal Chemistry Letters
https://doi.org/10.1016/j.bmcl.2008.09.054