Search results for "Aminosugar"

showing 3 items of 3 documents

Uridine enhances the cytotoxic effect of D-glucosamine in rat C6 glioma cells.

1986

This paper studies the influence of uridine on the effects exerted by D-glucosamine in rat C6 glioma cells. 2 mM uridine increased markedly both the cytotoxic effect of the aminosugar and the inhibition of thymidine incorporation into acid-insoluble fraction. Furthermore the complete resumption of the capacity to incorporate either 3H-thymidine or 3H-mannose which was observed after the removal of the aminosugar, was impeded when the cells were treated contemporaneously with D-glucosamine and uridine. An exposure for 4 hr to 20 mM glucosamine alone enhanced about 15-fold the cellular pool of UDP-N-acetylhexosamines; the addition of 2 mM uridine intensified the expansion of this pool, which …

Cell SurvivalBiologyC6 gliomaGeneral Biochemistry Genetics and Molecular BiologyCell Linechemistry.chemical_compoundGlucosamineGliomamedicineCytotoxic T cellAnimalsGeneral Pharmacology Toxicology and PharmaceuticsCytotoxicityUridineGlucosamineUridine Diphosphate N-AcetylglucosamineDrug SynergismGeneral MedicineGliomamedicine.diseaseMolecular biologyUridineIn vitroRatsBiochemistrychemistryAminosugarcytotoxic effectMannoseThymidineLife sciences
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NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular ima…

2008

This report concerns synthesis, (68)Ga-radiolabelling and stability data of 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-isothio-cyanatophenyl-acetic acid (NODAPA-NCS), 1,4,7-triazacyclononane-1-acetic acid-4,7-di-p-isothiocyanatophenyl-acetic acid (NODAPA-(NCS)(2)) and 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenyl-acetic acid (NODAPA-OH), versatile bifunctional chelators with potential for molecular imaging. Protein binding and exemplified conjugation are also reported.

PhenylacetatesStereochemistryChemistry PharmaceuticalClinical BiochemistryLysinePharmaceutical ScienceGallium RadioisotopesIn Vitro TechniquesBiochemistryChemical synthesisHeterocyclic Compounds 1-Ringchemistry.chemical_compoundHeterocyclic CompoundsDrug DiscoveryChelationBifunctionalMolecular BiologyChelating AgentsPhenylacetatesRadioisotopesOrganic ChemistryHydrogen-Ion ConcentrationModels ChemicalchemistryAminosugarDrug DesignIsotope LabelingPositron-Emission TomographyMolecular MedicineChemical stabilityMolecular imagingBioorganic & Medicinal Chemistry Letters
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The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells

1984

D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos.

Thymidine kinase activityanimal structuresChick EmbryoInhibitory postsynaptic potentialThymidine KinaseRetinaHeLaCellular and Molecular Neurosciencechemistry.chemical_compoundGlucosamineSettore BIO/10 - BiochimicaAnimalsHumansMolecular BiologyPharmacologyGlucosaminebiologyAge FactorsEmbryoDNACell Biologybiology.organism_classificationMolecular biologyD-glucosamine Retina HeLa Cell ThymidineKinase Activity Embryonic DevelopmentBiochemistrychemistryAminosugarThymidine kinaseembryonic structuresMolecular MedicineFemaleThymidineHeLa CellsThymidine
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