6533b871fe1ef96bd12d1113
RESEARCH PRODUCT
Translation of Basic Research into Clinics: Killer Immunoglobulin-like Receptors Genes in Autoimmune and Infectious Diseases
Anna AielloDanilo Di BonaCandoregiuseppinaGiulia AccardiClaudia ColombaMattia Emanuela LigottiGiovanni DuroCalogero CarusoCaterina Maria Gambinosubject
0301 basic medicinechemical and pharmacologic phenomenaImmunogeneticsHuman leukocyte antigenCommunicable DiseasesAutoimmune DiseasesPathogenesisimmunogenetic03 medical and health sciencestranslational medicineReceptors KIRDrug DiscoveryAutoimmune diseaseotorhinolaryngologic diseasesHumansviral infections.ReceptorPathogenGenePharmacologySettore MED/04 - Patologia GeneraleInnate immune systembiologyhemic and immune systemsImmunity InnateKIR030104 developmental biologyHLA ligandImmunologybiology.proteinAntibodydescription
Killer immunoglobulin-like receptors (KIRs) regulate the activation of natural killer cells through their interaction with human leucocyte antigens (HLA). KIRs and HLA loci are highly polymorphic, and some of their combinations have been found to protect against viral infections or to predispose to autoimmune disorders. In particular, some activating KIRs profiles may be detrimental in autoimmune pathogenesis, and specific KIRs may be particularly aggressive in the clearance of different microorganisms, protecting individuals in the control of a given pathogen. So, considering that in the pathogenesis of many autoimmune disorders and infections innate immunity plays a key role, the recent development for KIRs characterization, diseases monitoring, and treatment becomes obvious. Here, we reviewed a growing body of evidence supporting the influence of KIRs variants and their interaction with ligands in the development of the main human autoimmune and viral diseases, highlighting the main applications in clinical practice.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-27 |