6533b871fe1ef96bd12d1158
RESEARCH PRODUCT
Zinc acexamate inhibits gastric acid and pepsinogen secretion in the rat.
J EspluguesGines EscolarCarmen NavarroLuz GilJuan V. EspluguesOriol Bulbenasubject
medicine.medical_specialtyCarbacholPharmaceutical Sciencechemistry.chemical_elementZincGastric Acidchemistry.chemical_compoundPepsinInternal medicinemedicineGastric mucosaAnimalsAnesthesiaPylorusPharmacologyAminocaproatesbiologyPepsinogensChemistryStomachRatsGastric chief cellPerfusionmedicine.anatomical_structureEndocrinologyGastric MucosaAminocaproic Acidbiology.proteinGastric acidHistaminemedicine.drugdescription
Abstract Pretreatment with zinc acexamate (25–100 mg kg−1 i.p.) inhibited acid and pepsinogen secretion in the pylorus-ligated rat. Zinc acexamate (5–50 mg kg−1 p.o.) also inhibited the increases in acid secretion induced by carbachol (10 μg kg−1) and 2-deoxy-D-glucose (200 mg kg−1) in the perfused stomach of the anaesthetized rat. A delayed antisecretory effect was observed with this drug on histamine induced responses. High concentrations of zinc acexamate (10−5-10−2 M) did not modify the in-vitro activity of pepsin. Administration of zinc acexamate resulted in an increase in the presence of pepsinogen at the mucosal level. A morphological examination of the gastric mucosa confirmed an accumulation of zymogencontaining granules in the gastric chief cells of zinc acexamate-treated rats (50 mg kg−1 p.o.). These results indicate that zinc acexamate decreases acid and pepsinogen secretion in-vivo, and this may explain its antiulcer activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-04-01 | The Journal of pharmacy and pharmacology |