6533b871fe1ef96bd12d1170

RESEARCH PRODUCT

Anticomplementary Activity of Guinea Pig Serum Euglobulin: Its Relation to C 1 and to TAMe Esterase

P. Klein

subject

Guinea pigChemistryStereochemistryTAME esteraseFluid phaseReactivity (chemistry)Chemical reactionImmune complex

description

The interaction of complement with a suitable antigen-antibody aggregate triggers a chain of chemical reactions involving consecutively the nine factors of complement (C1 to C9). The triggering reaction is identical with the material fixation of Cl to the immune complex ; this leads to the formation of Ag-Ab-C1. By its fixation Cl is converted from its chemically inert form to a highly reactive state (“fixed” or “activated” C1). The reactivity of fixed Cl is directed first against C4. Consequently C4 rapidly disappears from the fluid phase in the presence of fixed Cl. A strikingly similar process occurs spontaneously in a fraction of guinea pig serum [5, 6].

yearjournalcountryeditionlanguage
1969-01-01
https://doi.org/10.1007/978-3-642-49733-9_3