6533b871fe1ef96bd12d120c

RESEARCH PRODUCT

HIFU for Bone Metastases and other Musculoskeletal Applications

Cesare GagliardoCarlo CatalanoMichele AnzideiAlessandro NapoliRoberto ScipioneAlberto Bazzocchi

subject

Osteoid osteomamedicine.medical_specialtymedicine.medical_treatment030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineinterventional radiologymedicineRadiology Nuclear Medicine and imagingbone metastasemedicine.diagnostic_testbusiness.industryVascular malformationUltrasoundBone metastasisMagnetic resonance imagingInterventional radiologymedicine.diseaseosteoid osteomaHigh-intensity focused ultrasoundCoagulative necrosisHigh-intensity focused ultrasoundpain palliation030220 oncology & carcinogenesisRadiologyCardiology and Cardiovascular Medicinebusiness

description

AbstractHigh-intensity focused ultrasound (HIFU) is a totally noninvasive procedure that has shown promising results in the management of numerous malignant and nonmalignant conditions. Under magnetic resonance or ultrasound guidance, high-intensity ultrasound waves are focused on a small, well-defined target region, inducing biologic tissue heating and coagulative necrosis, thus resulting in a precise and localized ablation. This treatment has shown both great safety and efficacy profiles, and may offer a multimodal approach to different diseases, providing pain palliation, potential local tumor control, and, in some cases, remineralization of trabecular bone. In musculoskeletal field, HIFU received FDA approval for treating bone metastasis, but its application has also been extended to other conditions, such as osteoid osteoma, desmoid tumor, low-flow vascular malformation, and facet joint osteoarthritis. This article illustrates the basic principles of HIFU and its main effects on biologic tissues with particular attention on bone, provides a step-by-step description of the HIFU procedure, and discusses the commonly treated conditions, in particular bone metastases.

yearjournalcountryeditionlanguage
2018-10-01
10.1055/s-0038-1673363http://hdl.handle.net/10447/311314