6533b871fe1ef96bd12d17f4
RESEARCH PRODUCT
ChemInform Abstract: Electrophilic Substitution and Cyclization of 2,2′-Bis(N-methylindolyl) : A Simple Access to Potential Protein Kinase C Inhibitor.
Dieter SchollmeyerUlf PindurYoung-shin Kimsubject
Electrophilic substitutionChemistryElectrophileReactivity (chemistry)General MedicineCombinatorial chemistryProtein kinase Cdescription
A strategy is described for the synthesis of functionalized and cyclized 2,2′-bisindolyl derivatives related to several basic systems of natural products. The starting 2,2′-bis(N-methylindolyl) (8) reacts with a variety of electrophiles and electrophilic dienophiles to furnish the novel, functionalized and cyclized bisindolyl derivatives 9–16. In addition, some reactivity and structural aspects are discussed; an X-ray crystallographic analysis of the 2,2′-bisindolyl 8 provided valuable information for the conformational analyses.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-18 | ChemInform |