6533b871fe1ef96bd12d1a47
RESEARCH PRODUCT
Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons
A. CestelliMassimo CoppolinoMaria ScaturroGiovanni SavettieriDaniele CastigliaMaria MonteItalia Di LiegroGiuseppe SalemiTommaso Nastasisubject
Gene isoformmedicine.medical_specialtySynapsin ITime FactorsTranscription GeneticBlotting Westernsynapsin IGene ExpressionBiologyBiochemistryCellular and Molecular Neurosciencechemistry.chemical_compoundFetusInternal medicineSettore BIO/10 - BiochimicaGene expressionmedicineAnimalsRNA MessengerNeurotransmitterCells CulturedCell NucleusCerebral CortexNeuronsMessenger RNANeuroscience (all)Cell DifferentiationGeneral MedicineSynapsinBlotting NorthernSynapsinsthyroid hormoneRatsCell biologyKineticsmedicine.anatomical_structureEndocrinologynervous systemchemistryNeuronal differentiationSynaptic plasticityTriiodothyronineSettore MED/26 - NeurologiaNeurondescription
Synapsin I is a neuron-specific protein which is present in two isoforms, Ia and Ib. In the last few years this protein has been demonstrated to play a central role in the regulation of neurotransmitter release and synaptic plasticity. In this paper the developmental expression of this protein has been investigated in primary neuronal cultures from fetal rat brain cortices. The presence of thyroid hormone in the culture medium stimulates an early expression of the protein without exerting any effect at the level of mRNA transcription and accumulation. These observations implicate a T3-dependent regulation of this neuron-specific gene at the level of mRNA translation. © 1995 Plenum Publishing Corporation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-02-01 |