The Antiviral Properties of Cyclosporine. Focus on Coronavirus, Hepatitis C Virus, Influenza Virus, and Human Immunodeficiency Virus Infections

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RESEARCH PRODUCT

The Antiviral Properties of Cyclosporine. Focus on Coronavirus, Hepatitis C Virus, Influenza Virus, and Human Immunodeficiency Virus Infections

Leszek Blicharz Anna Stochmal Mariusz Sikora Paulina Glowacka Patrycja Gajda Adriana Rakowska Malgorzata Olszewska Mohamad Goldust Mohamad Goldust Mohamad Goldust Lidia Rudnicka Olga Warszawik-hendzel

subject

0301 basic medicine medicine.medical_specialty viruses medicine.medical_treatment Hepatitis C virus coronavirus Review Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Organ transplantation 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Rotavirus medicine cyclosporine infections tacrolimus lcsh:QH301-705.5 Coronavirus human papilloma virus infection General Immunology and Microbiology Hepatitis C medicine.disease calcineurin inhibitors human herpesvirus Virology Tacrolimus AIDS hepatitis flu 030104 developmental biology Immunosuppressive drug lcsh:Biology (General)cyclophilin General Agricultural and Biological Sciences

description

This review updates current knowledge regarding the risk of viral infections, including COVID-19, in patients treated with cyclosporine. We also shortly refer to bacterial infections and parasitic infestations in patients treated with cyclosporin. Cyclosporine is an immunosuppressive drug, which is widely used in medicine, including in the treatment of autoimmune skin diseases in dermatology, rheumatology, ophthalmology and nephrology, and in organ transplantation. A usual concern associated with immunosuppressive treatment is the potential risk of infections. Interestingly, several data indicate a relatively low risk of infections, especially viral infections, in patients receiving cyclosporine. It was shown that cyclosporine exerts an inhibitory effect on the replication of some viruses, or may have a potentially beneficial effect on the disease course in infections. These include hepatitis C, influenza virus, rotavirus, human immunodeficiency virus and coronavirus infections. Available data indicate that cyclosporine may have a beneficial effect on COVID-19, which is caused by the coronavirus SARS-COV2.

year	journal	country	edition	language
2020-07-01	Biology

https://doi.org/10.3390/biology9080192