6533b871fe1ef96bd12d1b4a

RESEARCH PRODUCT

A New Steroidal Saponin from Dioscorea cayenensis

Marc SautourMarie Aleth Lacaille-duboisAnne Claire Mitaine-offerAlain Bertrand DongmoTomofumi Miyamoto

subject

chemistry.chemical_classificationbiologyDioscoreaPlant ExtractsStereochemistryDioscoreaceaeProtodioscinSaponinProsapogenin APhytosterolsGeneral ChemistryGeneral MedicineSaponinsbiology.organism_classificationRhizomechemistry.chemical_compoundchemistryCandida albicansDrug DiscoveryHumansDioscorea cayenensisDioscoreaCandida albicansRhizome

description

The new 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-20,22-seco-25(R)-furost-5-en-20,22-dione-3-O-alpha-L-rhamnopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 microg/ml, respectively), whereas saponins 1-3 were inactive.

yearjournalcountryeditionlanguage
2004-11-02Chemical and Pharmaceutical Bulletin
https://doi.org/10.1248/cpb.52.1353