6533b871fe1ef96bd12d1b95
RESEARCH PRODUCT
Effects of the novel polymer gel LeGoo on human internal thoracic arteries.
Peter MattFaik EleziFlorian RueterElse Müller-schweinitzerThomas GrussenmeyerMartin GrapowMoritz A. KonerdingBernhard WinklerFriedrich Ecksteinsubject
Pulmonary and Respiratory MedicineMaleEndotheliumInternal thoracic arteryPoloxamerMuscle Smooth VascularNorepinephrinemedicine.arteryMedicineHumansNew devicePolymer gelThoracic arteryMammary ArteriesAgedbusiness.industryOrgan bathAnatomyMiddle AgedAcetylcholinemedicine.anatomical_structureSurgeryFemaleEndothelium VascularCardiology and Cardiovascular MedicinebusinessTemporary occlusionAcetylcholinemedicine.drugdescription
Purpose Established hemostatic devices can injure vessel wall integrity. LeGoo (Pluromed, Woburn, MA), a novel poloxamer gel with reverse thermosensitive properties, is a new device for temporary occlusion of blood vessels. The present study investigated the effects of LeGoo on vascular function and morphology. Description The distal end of the human internal thoracic artery was used to assess vascular function of LeGoo-applied segments in organ bath experiments and by scanning electron microscopy. Evaluation After LeGoo application, both maximal contractile responses to noradrenaline and endothelium-dependent relaxant responses to acetylcholine were significantly reduced. Scanning electron microscopy showed areas of injured endothelium with exposure of subendothelial structures being in line with the functional changes. Conclusions Data suggested that application of LeGoo induced significant endothelial injury and deterioration of the smooth muscle in human internal thoracic arteries.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-12-01 | The Annals of thoracic surgery |