6533b871fe1ef96bd12d1ba5

RESEARCH PRODUCT

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy.

Felicia Gabriela GligorCarmen Maximiliana DobreaAnca Maria ArseniuMaria TotanAdina FrumAdriana Aurelia ChisAnca Maria JuncanAnca ButucaClaudiu MorgovanLuca-liviu Rus

subject

DrugDendrimersmedicine.medical_treatmentmedia_common.quotation_subjectGenetic VectorsPharmaceutical ScienceEnzyme TherapyComputational biologyReviewdendrimerdelivery vehiclesAnalytical ChemistryTargeted therapyViral vectornon-viral vectorQD241-441DendrimerGDEPTDrug DiscoverymedicineAnimalsHumansProdrugsPhysical and Theoretical ChemistryGenemedia_commonchemistry.chemical_classificationGDEP therapyImmunogenicityOrganic ChemistrytransgeneGene Transfer TechniquesGenetic TherapyProdrugtargeted therapyEnzymesEnzymechemistrygene delivery systemChemistry (miscellaneous)Molecular MedicineNanoparticles

description

Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher specificity, ease of synthesis and greater flexibility for subsequent modulations. Dendrimers used as delivery vehicles offer many advantages, such as: nanoscale size, precise molecular weight, increased solubility, high load capacity, high bioavailability and low immunogenicity. The aim of the present work was to provide a comprehensive overview of the recent advances regarding the use of dendrimers as non-viral carriers in the GDEPT therapy.

yearjournalcountryeditionlanguage
2021-10-01Molecules (Basel, Switzerland)
10.3390/molecules26195976https://pubmed.ncbi.nlm.nih.gov/34641519