Inhibitory effects oftrans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells

6533b871fe1ef96bd12d1bb1

RESEARCH PRODUCT

Inhibitory effects oftrans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells

Gérard Lizard Gérard Lizard Norbert Latruffe Norbert Latruffe Anna-kristina Marel Dominique Delmas Jean-claude Izard

subject

Cell Membrane Permeability endocrine system diseases vineatrol MESH: Cell Cycle MESH: DNA Replication MESH: Flow Cytometry resveratrol Resveratrol MESH : Antineoplastic Agents Phytogenic Wine grape chemistry.chemical_compound MESH: Structure-Activity Relationship MESH: Stilbenes Stilbenes MESH : Structure-Activity Relationship MESH: Cell Membrane Permeability skin and connective tissue diseases food and beverages DNA Neoplasm MESH : Cell Division Cell cycle Flow Cytometry MESH : Colonic Neoplasms colon cancer Biochemistry Colonic Neoplasms MESH: Cell Division cell cycle MESH : DNA Neoplasm Cell Division hormones hormone substitutes and hormone antagonists MESH : DNA Replication Biotechnology DNA Replication MESH: Xenobiotics MESH: Cell Line Tumor MESH : Flow Cytometry MESH: Antineoplastic Agents Phytogenic MESH: DNA Neoplasm MESH : Xenobiotics Biology Xenobiotics MESH : Stilbenes Structure-Activity Relationship Cell Line Tumor MESH : Cell Cycle [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Humans Structure–activity relationship [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular Biology polyphenols S phase MESH: Colonic Neoplasms MESH: Humans MESH : Cell Line Tumor Cell growth organic chemicals MESH : Humans Antineoplastic Agents Phytogenic chemistry MESH : Cell Membrane Permeability Acetylation Cell culture Cancer research Food Science

description

International audience; Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-Viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma.

year	journal	country	edition	language
2008-05-01	Molecular Nutrition & Food Research

https://doi.org/10.1002/mnfr.200700185