6533b871fe1ef96bd12d1c4c

RESEARCH PRODUCT

Sleep apnoea and metabolic dysfunction.

Ronald R. GrunsteinElizabeth MachanAnne-laure BorelMaria R. Bonsignore

subject

Pulmonary and Respiratory Medicinemedicine.medical_specialtymedicine.medical_treatmentReviewDiseaseType 2 diabetesSettore MED/10 - Malattie Dell'Apparato Respiratoriostomatognathic systemRisk FactorsSleep and breathingDiabetes mellitusmedicineAnimalsHumansObesityContinuous positive airway pressureIntensive care medicineLungMetabolic Syndromelcsh:RC705-779Sleep Apnea ObstructiveContinuous Positive Airway Pressurebusiness.industryRespirationSleep apnealcsh:Diseases of the respiratory systemmedicine.diseaseObesitynervous system diseasesrespiratory tract diseasesdiabetes metabolic syndrome weight lossTreatment OutcomeAdipose TissuePhysical therapyMetabolic syndromebusinessRisk Reduction BehaviorSignal Transduction

description

Obstructive sleep apnoea (OSA) is a highly prevalent condition often associated with central obesity. In the past few years, several studies have analysed the potential independent contribution of OSA to the pathogenesis of metabolic abnormalities, including type 2 diabetes, the metabolic syndrome and non-alcoholic fatty liver disease. New perspectives in OSA patient care have been opened by the promotion of lifestyle interventions, such as diet and exercise programmes that could improve both OSA and the metabolic profile. The rich clinical literature on this subject, together with the growing amount of data on pathophysiological mechanisms provided by animal studies using the chronic intermittent hypoxia model, urged the organising Committee of the Sleep and Breathing meeting to organise a session on sleep apnoea and metabolic dysfunction, in collaboration with the European Association for the Study of Diabetes. This review summarises the state-of-the-art lectures presented in the session, more specifically the relationship between OSA and diabetes, the role of OSA in the metabolic consequences of obesity, and the effects of lifestyle interventions on nocturnal respiratory disturbances and the metabolic profile in OSA patients.

yearjournalcountryeditionlanguage
2013-09-01
10.1183/09059180.00003413http://hdl.handle.net/10447/99298