Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana.

6533b871fe1ef96bd12d243c

RESEARCH PRODUCT

Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana.

Maurice Tagatsing Fotsing Salvador Máñez Emmanuel Yankep M. Carmen Recio José Luis Ríos Dieudonné Njamen Jean Claude Mbanya Rosa M. Giner Zacharias Tanee Fomum

subject

Blood Platelets medicine.drug_class Flavonoid Pharmaceutical Science Plant Roots Anti-inflammatory Millettia Phospholipases A Analytical Chemistry chemistry.chemical_compound Drug Discovery Botany medicine Leukocytes Animals Edema Humans Cameroon Spectral data Nuclear Magnetic Resonance Biomolecular Pharmacology chemistry.chemical_classification Flavonoids Chloroform Plants Medicinal Traditional medicine biology Molecular Structure Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Griffonianone D Ear Stereoisomerism biology.organism_classification Isoflavones Millettia Rats Phospholipases A Complementary and alternative medicine chemistry Prostaglandin-Endoperoxide Synthases visual_art visual_art.visual_art_medium Plant Bark Molecular Medicine Bark

description

A new isoflavone, griffonianone D (1), and the previously known compounds durmillone and odorantin were isolated from a chloroform extract of the root bark of Millettia griffoniana. The structure of 1 was established as (7E)-(6",7"-dihydroxy-3",7"-dimethyloct-2"-enyl)oxy-4'-methoxyisoflavone on the basis of its spectral data. The chloroform extract of the root bark of M. griffoniana and compound 1 showed anti-inflammatory effects in different experimental models of inflammation.

year	journal	country	edition	language
2003-09-27	Journal of natural products

10.1021/np0205912 https://pubmed.ncbi.nlm.nih.gov/14510620

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