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RESEARCH PRODUCT
Expression of KIT (CD117) in Biphasic Pulmonary Blastoma. Novel Data on Histogenesis
C. KortsikFernando BittingerTorsten HansenCharles James KirkpatrickB. Wagnersubject
MalePulmonary and Respiratory MedicineMesodermPathologymedicine.medical_specialtyLung NeoplasmsStromal cellbiologyCD117Biphasic Pulmonary BlastomaMesenchymal stem cellStem cell factorMiddle AgedHistogenesisImmunohistochemistrydigestive system diseasesProto-Oncogene Proteins c-kitmedicine.anatomical_structurebiology.proteinmedicineHumansEndodermLungdescription
Biphasic pulmonary blastoma (BPB) is a rare primary neoplasm of the lung and its histogenesis is still uncertain. It has been proposed that BPB is derived from mesoderm or endoderm. Others suggested an origin from a single pluripotential cell. We present a case of a BPB with emphasis on expression of the stem cell factor receptor KIT (CD117). We describe a 61-year-old male patient with a BPB of the upper right lobe. Immunohistochemical analysis was performed using a panel of several antibodies including anti-CD117. Strong cytoplasmic expression of CD117 was found in the epithelium (cytokeratin-positive) as well as in the spindle cells (cytokeratin-negative). Expression of CD117 in both mesenchymal and epithelial cells suggests a single origin and supports the idea that BPB arises from a pluripotential cell that can differentiate into both stromal and epithelial morphologies. The role of CD117 in the pathogenesis of BPB and its possible therapeutic relevance require further investigation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-12-25 | Lung |