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RESEARCH PRODUCT
The problems and promises of research into human immunology and autoimmune disease
René E. M. ToesJane H. BucknerStephen SawcerFrauke ZippBart O. Roepsubject
T-LymphocytesTranslational researchmedicine.disease_causeAutoantigensGeneral Biochemistry Genetics and Molecular BiologyAutoimmunityAutoimmune DiseasesTranslational Research BiomedicalMiceRisk FactorsmedicineAnimalsHumansLack of knowledgeGenetic Predisposition to DiseaseAutoimmune diseaseB-Lymphocytesbusiness.industryGeneral Medicinemedicine.diseaseDisease Models AnimalDisease PresentationImmunologybusinessBiomarkersGenome-Wide Association Studydescription
Translational research in autoimmunity is hampered by a number of hurdles, including a lack of knowledge regarding initiating and pathologically relevant autoantigens, the low frequency of autoreactive pathogenic B and T cells, difficulty in accessing the affected tissue, differences between self-reactive and pathogen-specific lymphocytes, a lack of etiologically relevant preclinical animal models and the heterogeneity of disease presentation. Given the need for biomarkers and new therapeutics, it is imperative that these hurdles be surmounted.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-31 |