6533b871fe1ef96bd12d2642
RESEARCH PRODUCT
Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction
A. Palumbo PiccionelloSilvestre BuscemiPaola PierroAndrea PaceAngela Accardosubject
Nitroaldol reactionChemistryorganic chemicalsGeneral Chemical EngineeringEnantioselective synthesisSettore CHIM/06 - Chimica OrganicaGeneral Chemistrybiochemical phenomena metabolism and nutritionbacterial infections and mycosesCatalysischemistry.chemical_compoundYield (chemistry)Linezolidpolycyclic compoundsOrganic chemistryheterocyclic compoundsEnantiomeric excessasymmetric synthesis linezolid henry reaction antibioticsdescription
A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henry reaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields of the chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 | RSC Advances |