6533b871fe1ef96bd12d2659
RESEARCH PRODUCT
Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-Candida Agents: In Vitro Antifungal Screening, Molecular Docking Study, and Spectroscopic Investigation of their Binding Interaction with Bovine Serum Albumin
Andreea-iulia PricopieGabriel MarcLaurian VlaseDan Cristian VodnarAdriana GrozavBrîndușa TiperciucLuiza GainaOvidiu OnigaIoana IonuțAnca-maria ArseniuAdrian Pîrnăusubject
Pharmaceutical Sciencefluorescence quenchingContext (language use)01 natural sciencesAnalytical Chemistrylcsh:QD241-44103 medical and health scienceschemistry.chemical_compoundlcsh:Organic chemistryIn vivobovine serum albuminDrug DiscoverymedicinePhysical and Theoretical ChemistryBovine serum albuminThiazole030304 developmental biology13-thiazole0303 health sciencesbiology010405 organic chemistryLanosterolOrganic Chemistryanti-<i>Candida</i>Biological activitymolecular dockingIn vitro0104 chemical scienceschemistryBiochemistryChemistry (miscellaneous)biology.proteinMolecular MedicineFluconazolemedicine.drugdescription
In the context of there being a limited number of clinically approved drugs for the treatment of Candida sp.-based infections, along with the rapid development of resistance to the existing antifungals, two novel series of 4-phenyl-1,3-thiazole and 2-hydrazinyl-4-phenyl-1,3-thiazole derivatives were synthesized and tested in vitro for their anti-Candida potential. Two compounds (7a and 7e) showed promising inhibitory activity against the pathogenic C. albicans strain, exhibiting substantially lower MIC values (7.81 &mu
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-09-21 | Molecules |