Search results for "3-thiazole"

showing 10 items of 18 documents

Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-

2019

In the context of there being a limited number of clinically approved drugs for the treatment of Candida sp.-based infections, along with the rapid development of resistance to the existing antifungals, two novel series of 4-phenyl-1,3-thiazole and 2-hydrazinyl-4-phenyl-1,3-thiazole derivatives were synthesized and tested in vitro for their anti-Candida potential. Two compounds (7a and 7e) showed promising inhibitory activity against the pathogenic C. albicans strain, exhibiting substantially lower MIC values (7.81 μg/mL and 3.9 μg/mL, respectively) as compared with the reference drug fluconazole (15.62 μg/mL). Their anti-Candida activity is also supported by molecular docking studies, usin…

Molecular Docking Simulation13-thiazoleStructure-Activity RelationshipAntifungal Agentsbovine serum albuminfluorescence quenchingSerum Albumin Bovineanti-Candidamolecular dockingArticleCandidaMolecules (Basel, Switzerland)
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CCDC 1420809: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-13-thiazole-5-carboxamide butan-1-ol solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1420811: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-13-thiazole-5-carboxamide isopropyl acetate solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-Candida Agents: In Vitro Antifungal Screening, Molecular…

2019

In the context of there being a limited number of clinically approved drugs for the treatment of Candida sp.-based infections, along with the rapid development of resistance to the existing antifungals, two novel series of 4-phenyl-1,3-thiazole and 2-hydrazinyl-4-phenyl-1,3-thiazole derivatives were synthesized and tested in vitro for their anti-Candida potential. Two compounds (7a and 7e) showed promising inhibitory activity against the pathogenic C. albicans strain, exhibiting substantially lower MIC values (7.81 &mu

Pharmaceutical Sciencefluorescence quenchingContext (language use)01 natural sciencesAnalytical Chemistrylcsh:QD241-44103 medical and health scienceschemistry.chemical_compoundlcsh:Organic chemistryIn vivobovine serum albuminDrug DiscoverymedicinePhysical and Theoretical ChemistryBovine serum albuminThiazole030304 developmental biology13-thiazole0303 health sciencesbiology010405 organic chemistryLanosterolOrganic Chemistryanti-<i>Candida</i>Biological activitymolecular dockingIn vitro0104 chemical scienceschemistryBiochemistryChemistry (miscellaneous)biology.proteinMolecular MedicineFluconazolemedicine.drugMolecules
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CCDC 1538393: Experimental Crystal Structure Determination

2017

Related Article: Amlan K. Pal, David B. Cordes, Alexandra M. Z. Slawin, Cristina Momblona, Antonio Pertegás, Enrique Ortí, Henk J. Bolink, Eli Zysman-Colman|2017|RSC Advances|7|31833|doi:10.1039/C7RA06347D

Space GroupCrystallographyCrystal System(22'-bi-13-thiazole)-bis(2-(pyridin-2-yl)phenyl)-iridium hexafluorophosphateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 977989: Experimental Crystal Structure Determination

2014

Related Article: Yozane Hokai, Boruch Jurkowicz, Jacob Fernández-Gallardo, Nuruddinkodja Zakirkhodjaev, Mercedes Sanaú, Theodore R. Muth, María Contel|2014|J.Inorg.Biochem.|138|81|doi:10.1016/j.jinorgbio.2014.05.008

Space GroupCrystallographyCrystal System(mu-11'-bis(diphenylphosphino)ferrocene)-bis(45-dihydro-13-thiazole-2-thiolato)-di-goldCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1420810: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-13-thiazole-5-carboxamide 14-dioxane solvateExperimental 3D Coordinates
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CCDC 1420812: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-13-thiazole-5-carboxamide propan-2-ol solvateExperimental 3D Coordinates
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CCDC 1420814: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-13-thiazole-5-carboxamide butyl acetate solvateExperimental 3D Coordinates
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CCDC 2209229: Experimental Crystal Structure Determination

2022

Related Article: Miguel Gavara-Edo, Francisco Javier Valverde-Muñoz, Rosa Córdoba, M. Carmen Muñoz, Javier Herrero-Martín, José Antonio Real, Eugenio Coronado|2022|J.Mater.Chem.C|11|8107|doi:10.1039/D2TC04120K

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(dihydrogen bis(pyrazolyl)borate)-(44'55'-tetrahydro-22'-bi-13-thiazole)-ironExperimental 3D Coordinates
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