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RESEARCH PRODUCT

Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study.

Mario BarbagalloMaria NotarnicolaL DominguezJoseph FirthStefania MaggiNicola VeroneseBrendon StubbsBrendon StubbsBrendon StubbsMaria Gabriella Caruso

subject

0301 basic medicineMaleLongitudinal studymedicine.medical_specialtySettore MED/09 - Medicina InternaFrail ElderlyOsteoarthritis Initiative; frailty; magnesium; older adultslcsh:TX341-641OsteoarthritisfrailtymagnesiumLower riskRecommended Dietary AllowancesArticle03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineHumans030212 general & internal medicineLongitudinal StudiesOlder adultolder adultsAgedMagnesium/administration & dosage030109 nutrition & dieteticsNutrition and Dieteticsbusiness.industryConfoundingHazard ratioOsteoarthritis Knee/etiologyfrailty; magnesium; older adults; Osteoarthritis InitiativeMiddle AgedOsteoarthritis Kneemedicine.diseaseConfidence intervalDietFrailty; Magnesium; Older adults; Osteoarthritis Initiative; Food Science; Nutrition and DieteticsDietary Reference IntakeOsteoarthritis InitiativePhysical therapyFemaleOlder peoplebusinesslcsh:Nutrition. Foods and food supplyFood Science

description

Inadequate magnesium (Mg) intake is associated with lower physical performance, but the relationship with frailty in older people is unclear. Therefore, we aimed to investigate whether higher dietary Mg intake is associated with a lower risk of frailty in a large cohort of North American individuals. Details regarding Mg intake were recorded through a food-frequency questionnaire (FFQ) and categorized as greater than/equal to Recommended Dietary Allowance (RDA) vs. lower. Frailty was defined using the Study of Osteoporotic Fractures index. Multivariable Cox’s regression analyses, calculating hazard ratios (HRs) with 95% confidence intervals (CIs), were undertaken by sex. In total, 4421 individuals with knee osteoarthritis or who were at high risk without frailty at baseline (mean age: 61.3, females = 58.0%) were followed for 8 years. After adjusting for 11 potential baseline confounders, reaching the RDA for Mg lowered risk of frailty among men (total n = 1857, HR = 0.51; 95% CI: 0.26–0.93), whilst no significant associations were found in women (total n = 2564). Each 100 mg of dietary Mg intake at baseline corresponded to a 22% reduction in men (HR = 0.78; 95% CI: 0.62–0.97; p = 0.03), but not in women (HR = 1.05; 95% CI: 0.89–1.23). In conclusion, higher dietary Mg intake appears to reduce the risk of frailty in men, but not in women.

yearjournalcountryeditionlanguage
2017-11-16Nutrients
10.3390/nu9111253https://pubmed.ncbi.nlm.nih.gov/29144404