6533b871fe1ef96bd12d26ca
RESEARCH PRODUCT
Novel immunotherapies in multiple myeloma – chances and challenges
Leo RascheHartmut GoldschmidtMarkus MunderRalph WäschMarc S. Raabsubject
Immunoconjugatesbusiness.industryT-LymphocytesHematologyReview ArticleBioinformaticsmedicine.diseaseChimeric antigen receptorReview articleAntibodies BispecificMedicineHumansImmunotherapybusinessMultiple MyelomaMultiple myelomadescription
In this review article, we summarize the latest data on antibody-drug conjugates, bispecific T-cell-engaging antibodies, and chimeric antigen receptor T cells in the treatment of multiple myeloma. We discuss the pivotal questions to be addressed as these new immunotherapies become standard agents in the management of multiple myeloma. We also focus on the selection of patients for these therapies and speculate as to how best to individualize treatment approaches. We see these novel immunotherapies as representing a paradigm shift. However, despite the promising preliminary data, many open issues remain to be evaluated in future trials.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-07-01 | Haematologica |