6533b872fe1ef96bd12d3063
RESEARCH PRODUCT
Granulometric analysis of corneal endothelium specular images by using a germ–grain model
M. E. DíazRafael SebastianGuillermo AyalaLucía Martínez-costasubject
Corneal endotheliumMaterials sciencegenetic structuresCell CountHealth InformaticsCell densityImage Processing Computer-AssistedHumansComputer SimulationComputer visionGermSpecular reflectionCell SizeMicroscopyFourier Analysisbusiness.industryBinary imageEndothelium CornealNumerical Analysis Computer-AssistedComputer Science ApplicationsOphthalmoscopySPECULAR MICROSCOPYArtificial intelligenceBiological systembusinessSoftwareShape analysis (digital geometry)description
Specular microscopy is widely used to study the human corneal endothelium status in vivo. In this paper, the corneal endothelium is represented as a binary image composed of the cell inscribed circles. The granulometric distribution function of the complement of this image is used as a functional descriptor, which provides information about the shape, size and spatial arrangement of cells. Experimental evaluation using bootstrap techniques shows its ability to discriminate between controls and pathological cases. It represents a reliable and graphical alternative to the classical indices (cell density, hexagonality and coefficient of variation of cell areas), which behave poorly when detecting subtle abnormalities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-03-01 | Computers in Biology and Medicine |